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Luteolin inhibits the proliferation and metastasis of cancer cells by inhibiting certain tumor growth factors and signaling pathways (such as the MAPK and PI3K/Akt pathways) (47, 48), providing a theoretical basis for the prevention and treatment of endocrine diseases

Both of which follow diurnal rhythms controlled by BMAL1 (brain and muscle ARNT-like 1) and CLOCK gene expression

451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

Indeed, drug-free patients showed lower estimated VAS scores than patients who underwent concomitant pain therapy